Is there a safe in the room?
'Cassaforte' — stress 'CAS-sa-FOR-te'. The double S is pronounced longer than a single S.
Ask this at check-in or when you need to store valuables. Most mid-range and above hotels in Italy have in-room safes.
'C'è' (there is) is one of the most useful Italian constructions, combining 'ci' and 'è'. 'In camera' means 'in the room' — 'camera' in Italian refers specifically to a bedroom, not a generic room (which would be 'stanza' or 'sala').
La camera ha una cassaforte?
Does the room have a safe?
Alternative construction with 'ha' (has)
Posso usare la cassaforte per i miei valori?
Can I use the safe for my valuables?
Specifies purpose
Dov'è la cassaforte?
Where is the safe?
When you know there is one but need to locate it
Italian hotels are generally safe, but pickpocketing in tourist areas is common. Concierges may also offer to store valuables in the hotel's main safe at reception, which is a common alternative.