Excuse me, how do I get to the Cathedral?
ar-RI-vo — stress on second syllable. DUO-mo — stress on first syllable.
The classic Italian direction request — use this template for any landmark.
'Come arrivo a' (how do I get to) + destination is the most natural Italian direction question. 'Mi scusi' (excuse me, formal) is essential before approaching a stranger. 'Duomo' (cathedral/dome) refers to the main cathedral of an Italian city — Florence's is the most famous.
Come si va alla stazione?
How do you get to the station?
Impersonal 'si' version — slightly more casual
Qual è la strada per il centro storico?
What is the road to the historic centre?
Asking for a road rather than directions
Sono lontano dal Colosseo?
Am I far from the Colosseum?
Checking proximity before asking for directions
Every Italian city has a Duomo — the main cathedral. Florence's Duomo (Santa Maria del Fiore) with Brunelleschi's dome is perhaps the most iconic. When asking directions in Italy, locals are generally very helpful and often insist on accompanying you part of the way. Accept with gratitude — 'Grazie, è molto gentile.'